Cholera’s most severe complication is dehydration, leading to dangerous electrolyte imbalances, muscle and nerve dysfunction, and even hypovolemic shock. This rapid fluid loss can cause acute renal failure and make the body prone to secondary infections. In children, cholera often leads to hypoglycemia due to rapid nutrient loss. These complications highlight the need for immediate medical intervention, emphasizing that timely fluid and electrolyte replacement is crucial and potentially life-saving.